Don't think so. I've never had any issue with other games latency. I did however notice that every so often in DD2 my character will lag warp to a random location a few feet away from where I was running, sometimes nearly killing me. I believe this is one of those games that, instead of hosting servers for us to play on, one player is the host and everyone is just connecting to him. If that's the case, then NAT will cause a lot of issues such as that. My current NAT should be open, but having been a network engineer in the past, I know that's not always the case.